Kidney Res Clin Pract.  2022 Sep;41(5):533-544. 10.23876/j.krcp.22.069.

Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies

Affiliations
  • 1Dialysis and Transplantation Unit, Division of Nephrology, Department of Medicine, School of Medicine, University of Padova, Padova, Italy

Abstract

The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types (endothelial cells, smooth muscle cells, macrophages, and others), components of the vasculature, glomeruli, and heart that are susceptible to oxidative damage and structural alterations. A vicious cycle occurs whereby harmful factors such as reactive oxygen species and inflammation damage of vascular structures that themselves become sources of additional dangerous/toxic components released into the local environment. The evidence of this vicious cycle in chronic kidney disease should therefore lead to add other factors to both traditional and nontraditional risk factors. This review will examine the processes occurring during progressive kidney dysfunction with regard to vascular injury, renal remodeling, cardiac hypertrophy, and the transversal role of oxidative stress in the development of these complications.

Keyword

Antioxidant response; Inflammation; Kidney; Reactive oxygen species; Redox balance
Full Text Links
  • KRCP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr