Brain Tumor Res Treat.  2022 Oct;10(4):221-225. 10.14791/btrt.2022.0039.

Medical Treatment of Pediatric Low-Grade Glioma

  • 1Department of Pediatrics, Chungnam National University College of Medicine, Deajeon, Korea


Low-grade glioma (LGG) is the most common brain tumor in children and has excellent long-term survival. With an excellent survival rate, the choice of treatment involves careful consideration of minimizing late toxicity from surgery, radiation, and chemotherapy. Surgery, radiation therapy, and chemotherapy can be used as monotherapy or in combination, providing different therapeutic ratios and complications. As a result, establishing the selection of ideal therapies has been a controversial area, presenting challenges. Recent advances in understanding molecular characteristics of pediatric LGG affect classification and treatment approaches. This review aims to overview recent developments in medical treatment in pediatric LGG.


Low grade glioma; Pediatric brain tumor; Chemotherapy; Target therapy
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