Blood Res.  2022 Sep;57(3):241-243. 10.5045/br.2022.2022074.

A rare case of pediatric immune thrombocytopenia with secondary antiphospholipid syndrome in Korea

• Ji YS
• Park SK
• Jeon BR
• Jang MA

• KMID: 2533254
• DOI: http://doi.org/10.5045/br.2022.2022074

Figure

• 

  Fig. 1 Computed tomography (CT) angiography and venous duplex ultrasound of the lower extremity in a pediatric patient with secondary antiphospholipid syndrome associated with immune thrombocytopenia. (A) In the lower extremity CT, a small focal filling defect (white arrow) was observed at the right distal superficial femoral vein suggesting deep vein thrombosis (DVT). (B) In the venous duplex ultrasound of the lower extremity, occlusion of the branch of right femoral vein and collateral veins was observed. (C) After 3 months of anticoagulation, follow-up duplex ultrasound showed improvement of DVT.

Reference

1. Del Vecchio GC, De Santis A, Accettura L, De Mattia D, Giordano P. 2014; Chronic immune thrombocytopenia in childhood. Blood Coagul Fibrinolysis. 25:297–9. DOI: 10.1097/MBC.0000000000000043. PMID: 24492401.

2. Kohli R, Chaturvedi S. 2019; Epidemiology and clinical manifestations of immune thrombocytopenia. Hamostaseologie. 39:238–49. DOI: 10.1055/s-0039-1683416. PMID: 30868551.

3. Jang JH, Kim JY, Mun YC, et al. 2017; Management of immune thrombocytopenia: Korean experts recommendation in 2017. Blood Res. 52:254–63. DOI: 10.5045/br.2017.52.4.254. PMID: 29333401. PMCID: PMC5762735.

4. Aguiar CL, Soybilgic A, Avcin T, Myones BL. 2015; Pediatric antiphospholipid syndrome. Curr Rheumatol Rep. 17:27. DOI: 10.1007/s11926-015-0504-5. PMID: 25854492. PMCID: PMC7843475.

5. Madison JA, Zuo Y, Knight JS. 2019; Pediatric antiphospholipid syndrome. Eur J Rheumatol. 7(Suppl 1):1–10. DOI: 10.5152/eurjrheum.2019.19160. PMID: 31804173. PMCID: PMC7004270. PMID: d579b647cdc34377ad16623a31731c82.

6. Avcin T, Cimaz R, Silverman ED, et al. 2008; Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry. Pediatrics. 122:e1100–7. DOI: 10.1542/peds.2008-1209. PMID: 18955411.

7. Miyakis S, Lockshin MD, Atsumi T, et al. 2006; International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 4:295–306. DOI: 10.1111/j.1538-7836.2006.01753.x. PMID: 16420554.

8. Hwang JJ, Shin SH, Kim YJ, et al. 2020; Epidemiology of antiphospholipid syndrome in Korea: a nationwide population- based study. J Korean Med Sci. 35:e35. DOI: 10.3346/jkms.2020.35.e35. PMID: 32030922. PMCID: PMC7008065.

9. Diz-Küçükkaya R, Hacihanefioğlu A, Yenerel M, et al. 2001; Antiphospholipid antibodies and antiphospholipid syndrome in patients presenting with immune thrombocytopenic purpura: a prospective cohort study. Blood. 98:1760–4. DOI: 10.1182/blood.V98.6.1760. PMID: 11535509.