Korean J Fam Pract.  2022 Sep;12(4):274-279. 10.21215/kjfp.2022.12.4.274.

Relationship of Heart Rate Variability with Triglyceride-Glucose Index among Korean Men and Women in a Primary Care Clinic

  • 1Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea
  • 2Department of Family Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea


Reduced heart rate variability (HRV) can be a predictor of all causes of death. Few studies have analyzed the association between HRV and the triglyceride-glucose (TyG) index in a primary care setting rather than in specific high-risk patients. This study aimed to investigate the relationship between HRV and the TyG index among Koreans at a primary care clinic.
This cross-sectional study included 1,991 participants who underwent HRV assessments and blood tests after fasting for more than 8 hours. Common HRV indices such as the standard deviation of normal-to-normal intervals (SDNN), the root mean square of successive difference (RMSSD), total power (TP), low frequency (LF), high frequency (HF), and the LF/HF ratio were measured. Individuals with a TyG index greater than 9.1 (≥75th percentile) were subclassified into a “high TyG index” group. Associations between the TyG index and HRV were investigated using multiple logistic regression analysis.
The individuals’ mean age was 46.6 years, and the high TyG index group included 244 of all 1,991 participants. Among the assessed HRV indices, the SDNN, RMSSD, and HF showed associations with the high TyG index group, with odd ratios of 0.98 (0.97–0.99), 0.98 (0.96–0.99), and 0.99 (0.99–1.00), respectively, after adjusting for age, sex, white blood cell count, total cholesterol, high density lipoprotein cholesterol, alanine aminotransferase, γ-glutamyltransferase, uric acid, creatinine, hypertension, and diabetes.
Among the common HRV indices, the SDNN, RMSSD, and HF were decreased in a subgroup of individuals with a high TyG index.


Heart Rate Variability; Autonomic Dysfunction; Triglyceride-Glucose Index; Insulin Resistance
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