Korean J Pancreas Biliary Tract.  2022 Jul;27(3):116-120. 10.15279/kpba.2022.27.3.116.

Surveillance for Pancreatic Cancer in Chronic Pancreatitis

• Chang JH

• KMID: 2532497
• DOI: http://doi.org/10.15279/kpba.2022.27.3.116

Abstract

Pancreatic cancer can arise in the background of chronic pancreatitis (CP). The relative risks for pancreatic cancer in CP vary considerably according to other contributing factors such as disease duration, excess alcohol consumption, tobacco consumption, eating habits, physical activity, and late-onset diabetes. The incidence of pancreatic cancer is estimated to be about 10 per 105 per year, and the incidence and prevalence of CP are estimated to be 5-12 per 105 and 50 per 105 per year, respectively. The pooled relative risk estimates for pancreatic cancer in CP patients range from 2.7 to 13.3. Subsets of CP subjects with a family history of pancreatic cancer or those with newly developed diabetes over the age of 50 have a higher risk for pancreatic cancer. However, the prevalence of pancreatic cancer is not high enough to justify general screening of the adult CP population. Thus, it is necessary to select subsets of CP cohorts with a significantly high risk of pancreatic cancer. We need a better overall disease model that can define the interaction of multiple risk factors and their cumulative or potential effects on pancreatic cancer.

Keyword

만성췌장염; 췌장신생물; 집단 감시; 암 조기 발견; Pancreatitis, chronic; Pancreatic neoplasms; Population surveillance; Early detection of cancer