J Vet Sci.  2022 Jul;23(4):e52. 10.4142/jvs.21310.

Clinical, virological, imaging and pathological findings in a SARS CoV-2 antibody positive cat

Affiliations
  • 1Zeytinburnu Veterinary Clinic, Merv Caddesi, 34025 Zeytinburnu, Istanbul, Turkey
  • 2Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, 34500 Buyukcekmece, Istanbul, Turkey
  • 3Louisiana Animal Disease Diagnostic Laboratory and Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
  • 4Department of Pathology, Veterinary Faculty, Istanbul University-Cerrahpasa, Buyukcekmece, 34500 Istanbul, Turkey
  • 5Department of Gynecology and Obstetric, Veterinary Faculty, Istanbul University-Cerrahpasa, 34320 Avcılar, Istanbul, Turkey
  • 6Department of Surgery, Veterinary Faculty, Istanbul University-Cerrahpasa, 34320 Avcılar, Istanbul, Turkey
  • 7Department of Microbiology, Veterinary Faculty, Istanbul University-Cerrahpasa, Buyukcekmece, 34500 Istanbul, Turkey
  • 8The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK
  • 9Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA

Abstract

This paper reports a presumptive severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection in a cat. A cat with respiratory disease living with three individuals with coronavirus disease 2019 showed bilateral ground-glass opacities in the lung on X-ray and computed tomography. The clinical swabs were negative for SARS-CoV-2 RNA, but the serum was positive for SARS-CoV-2 antibodies. Interstitial pneumonia and prominent type 2 pneumocyte hyperplasia were noted on histopathology. Respiratory tissues were negative for SARS-CoV-2 RNA or antigen, but the cat was positive for feline parvovirus DNA. In conclusion, the respiratory disease and associated pathology in this cat could have been due to exposure to SARS-CoV-2.

Keyword

Cat; SARS-CoV-2; antibody; X-ray; tomography; ground-glass opacity; interstitial pneumonia
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