J Korean Med Sci.  2022 Feb;37(8):e63. 10.3346/jkms.2022.37.e63.

Personal Exposure to Total VOC Is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

Affiliations
  • 1Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea
  • 2Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
  • 3Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
  • 4Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
  • 5Department of Data Science, Sejong University College of Software Convergence, Seoul, Korea
  • 6Department of Precision Medicine, Sungkyunkwan University School of medicine, Suwon, Korea
  • 7Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea

Abstract

Background
The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.
Methods
Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.
Results
Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.
Conclusion
Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Keyword

Volatile Organic Compounds; Urinary Metabolite; Atopic Dermatitis

Figure

  • Fig. 1 Random forest analysis of the contribution of different urinary VOC metabolites to presence of atopic dermatitis (A) and SCORADs (B).SCORAD = SCORing Atopic Dermatitis, VOC = volatile organic compound, BMI = body mass index.


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