J Vet Sci.  2022 Jan;23(1):e10. 10.4142/jvs.21169.

Reference values for selected dry eye tests in normal Beagle dogs: a pilot study

Affiliations
  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea
  • 2Dana Animal Hospital Eye Center, Seoul 07014, Korea

Abstract

Background
Dry eye disease (DED) cannot be diagnosed by a single test because it is a multifactorial disorder of the ocular surface. Although studies on various dry eye tests (DETs) in dogs have been reported, standard criteria have not been established except for the Schirmer tear test 1 (STT-1).
Objectives
To establish reference values for DETs in dogs with normal STT-1 values (≥ 15 mm/min) and to analyze the correlation between DETs.
Methods
The STT-1 was performed in 10 healthy Beagle dogs (20 eyes). After 20 min, interferometry (IF) for estimating the lipid layer thickness (LLT) of the tear film, tear meniscus height (TMH), non-invasive tear breakup time (NIBUT), and meibomian gland loss rate of the upper eyelid (MGLRU) and lower eyelid (MGLRL), were measured using an ocular surface analyzer.
Results
Mean values for STT-1, TMH, and NIBUT were as follows: 21.7 ± 3.4 mm/min, 0.41 ± 0.21 mm, and 19.1 ± 9.5 sec, respectively. The most frequent LLT range, measured by IF, was 30–80 nm (11 eyes), followed by 80 nm (5 eyes) and 80–140 nm (4 eyes). MGLRU ≤ 25% was measured in 11 eyes and 26%–50% in 9 eyes; MGLRL ≤ 25% in 8 eyes and 26%–50% in 12 eyes. Besides positive correlation between TMH and NIBUT (P = 0.038), there were no significant associations between DETs.
Conclusions
Data obtained in this study provided normative references that could be useful for diagnosing DED and for further research into correlation between DETs in dogs with DED.

Keyword

Dog; non-invasive tear breakup time; ocular surface analyzer; dry eye tests; tear meniscus height
Full Text Links
  • JVS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr