J Korean Acad Oral Health.  2021 Dec;45(4):239-243. 10.11149/jkaoh.2021.45.4.239.

Oral disease prevention effect of ginkgo-leaf-extract-containing-dentifrice

• Kim BH
• Shin KH
• Cho JW
• Park JH

• KMID: 2524202
• DOI: http://doi.org/10.11149/jkaoh.2021.45.4.239

Abstract

Objectives
The study evaluated the effects of dentifrice with the proper amount of ginkgo biloba extract in the prevention of gum disease through clinical trials.
Methods
Total sixty volunteers from the experimental group using experimental dentifrice (30 volunteers) and the control group using control dentifrice (30 volunteers) should use the experimental and control dentifrice for 8 weeks. Before the experiment, and 1, 2, 4, 6, and 8 weeks after the experiment, the papillary marginal attached gingival Index (the PMA index), Talbott’s gingival index, patient hygiene performance index (PHP index), and Tureski’s dental plaque index test were tested six times.
Results
As a result of the PMA index measurement, the experimental and control groups showed statistically significant differences after 6 weeks, and the experimental group showed a significant decrease in the PMA index from 4 weeks after the experiment. The patient hygiene performance index measurement results showed a statistically significant difference between the experimental group and the control group after 4 weeks, and the experimental group showed a significant decrease in the PHP index 2 weeks after the experiment.
Conclusions
The use of ginkgo-leaf-extract-containing-dentifrice confirmed that improved dental plaque removal, gingivitis relief, and periodontal disease prevention could be expected.

Keyword

Dental plaque; Dentifrices; Gingiva

Reference

References

1. Kim JB, Choi EG, Paik DI, Shin SC, Kim DK, Hong SJ. Clinical Preventive Dentistry. 2nd ed. Eewoo;Seoul: p. 75–104.

2. Kim BO, No EM, Jo MS, Bae SS, Kim SA, Seo EJ, et al. 2016. Periodontology. 4th ed. Daehannarae;Seoul: p. 238.

3. Paik DI, Kim HD, Jin BH, Park YD, Shin SC, Cho JW, et al. 2011. Clinical preventive dentistry. 5th ed. Komoonsa;Seoul: p. 81–114.

4. Jo MJ, Jwa SK. 2017; Tooth Whitening Effect of Manicure Type Hydrogen Peroxide Toothwhiening Gel. Int J Clin Prev Dent. 13(4):209–216. DOI: 10.15236/ijcpd.2017.13.4.209.

5. Kim NH, Mun SH, Kim AH, Min JH, Ahn JH, Ha WH, et al. 2011; The antimicrobial and anti-plaque effect of dentifrice containing baking soda and triclosan. J Korean Acad Oral Health. 35:10–17. DOI: 10.4094/jkachn.2011.17.1.10.

6. Hwang SJ, Kim SN, Chang SY, Ha WH, Kim IS, Jin BH, et al. 2005; Gingivitis suppression effect of the de novo dentifrice containing Curcuma xanthorrhiza, bamboo salt and various additives. J Korean Acad Oral Health. 29:451–462.

7. Han KS, Bae KH, Lee MJ, Choi JS. 2008; Evaluation of periodontal status according to sociodemographic and health behavior characteristics. J Dent Hyg Sci. 8:395–401.

8. Son JB, Seong JH, Kim DG. 2003; Desensitizing effect of toothpaste containing potassium phosphate on dentinal hypersensitivity. J Korean Acad Oral Health. 27:97–111.

9. Min KN. 2018; Physicochemical properties of Ginkgetin and Isoginkgetin extracted from Ginko leaves. J Korea Convergence Soc. 9:89–98.

10. Lee TR, Moon HS, Paik DI, Kim JB. 2008. Oral health statistics with e-Learning. 7th ed. Komoonsa;Seoul: p. 204–238.

11. Moon HS, Paik DI, Kim JB. 1996. Oral health statistics. 4th ed. Komoonsa;Seoul: p. 145–200.

12. Kim JB, Choi EG, Moon HS, Kim JB, Kim DK, Lee HS, Park DY. 2009. Public Health Dentistry. 5th ed. Komoonsa;Seoul: p. 349–430.

13. Ma DS, Lee BJ, Kim DK, et al. 2016. Preventive dentistry. 1st ed. Daehan Narae Publishing Inc.;Seoul: p. 43–122.

14. Addy M, Willis L, Moran J. 1983; Effect of toothpaste rinses compared with chlorohexidine of plaque formation during a 4-day period. J Clin Periodontol. 10:89–99. DOI: 10.1111/j.1600-051X.1983.tb01270.x. PMID: 6572638.

15. Omidkhoda SF, Razavi BM, Hosseinzadeh H. 2019; Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: A comprehensive review. Phytother Res. 33:2821–2840. DOI: 10.1002/ptr.6469. PMID: 31429152.

16. Cui Y, Li XX, Huang J. 2019; Effects of notoginseng and ginkgo leaf tablets on cardiac function and serum inflammatory factors in hypoxia deacclimatized rats and its mechanism. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 35:34–37. DOI: 10.12047/j.cjap.5705.2019.008. PMID: 31245950.

17. Yalçın E, Çavuşoğlu K, Acar A, Yapar K. 2020; In vivo protective effects of Ginkgo biloba L. leaf extract against hydrogen peroxide toxicity: cytogenetic and biochemical evaluation. Environ Sci Pollut Res Int. 27:3156–3164. DOI: 10.1007/s11356-019-07156-w. PMID: 31838678.

18. Guo J, Zhou X, Wang T, Wang G, Cao F. 2019; Regulation of flavonoid metabolism in ginkgo leaves in response to different day-night temperature combinations. Plant Physiol Biochem. 147:133–140. DOI: 10.1016/j.plaphy.2019.12.009. PMID: 31862579.

19. Li YY, Lu XY, Sun JL, Wang QQ, Zhang YD, Zhang JB, Fan XH. 2019; Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba. Chin J Nat Med. 17:672–681. DOI: 10.1016/S1875-5364(19)30081-0. PMID: 31526502.

20. Guo N, Jiang YW, Song XR, Li YY, Liu ZM, Fu YJ. 2019; Effect of Bacillus natto solid-state fermentation on the functional constituents and properties of Ginkgo seeds. J Food Biochem. 43:e12820. DOI: 10.1111/jfbc.12820. PMID: 31353517.