J Korean Soc Biol Ther Psychiatry.
2021 Oct;27(3):145-155.
Circadian Rhythm Disruption in Cancer Biology: A Review of Literature
- Affiliations
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- 1Department of Psychiatry, Seoul National University Hospital, Seoul, korea
Abstract
- Circadian rhythm is an oscillating biological rhythm that operates on a 24-hour cycle and is caused by an internal biological clock. Circadian rhythm regulates many physiological processes and behaviors in the human body, and it has been known that disturbance of circadian rhythm causes various diseases including cancer. The interaction between circadian rhythm and cancer appears in both directions, and chronotherapeutics, the concept of treatment according to circadian timing, has become particularly important in these days. In this article, we investigated the definition and physiological-behavioral outputs of circadian rhythm. The circadian rhythm disruption, circadian timing system and chronomodulated chemotherapy were reviewed in relation to cancer biology.
