Korean J Transplant.  2021 Oct;35(Supple 1):S143. 10.4285/ATW2021.OP-1181.

Transarterial Chemoembolization with radiotherapy for solitary hepatocellular carcinoma bone metastasis after living donor liver transplantation

• Han J
• Han YS

• KMID: 2521332
• DOI: http://doi.org/10.4285/ATW2021.OP-1181

Abstract

Background
Hepatocellular carcinoma (HCC) represents one of the most common causes of cancer-related deaths worldwide.Bone metastasis (BM) is a typical metastatic pattern in HCC patients. Although the treatment of HCC has improved in recent years, the prognosis of BM is poor, a median survival of HCC with BM is 1–2 months. However, the management of BM is palliative radiotherapy only. We present the cases, transarterial chemoembolization (TACE) with radiotherapy for solitary BM lesion.
Methods
Among 94 recipients who were received living donor liver transplantation due to HCC between December 2014 and July 2021, we had three cases of BM from HCC. They had solitary lesion and we performed the TACE with radiotherapy for curative treatment.
Results
Metastatic lesion was decreased or disappeared in radiologic finding after TACE, tumor marker was decreased in all cases. In spite of extremely poor prognosis of BM from HCC, patients have survived more than 6 months after the first recurrence event. There is no recurrence in other organ, except primary BM lesion.
Conclusions
BM in HCC is typical metastatic pattern, but the prognosis is poor. TACE with radiotherapy for solitary BM lesion could be a treatment option for the purpose of curative intend, compared to palliative radiotherapy.