Biomol Ther.  2021 Sep;29(5):536-544. 10.4062/biomolther.2020.227.

Hyaluronic Acid Increases Anti-Inflammatory Efficacy of Rectal 5-Amino Salicylic Acid Administration in a Murine Colitis Model

Affiliations
  • 1Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn 53121, Germany
  • 2Tris Pharma, Monmouth Junction, NJ 08852, USA
  • 3Bayer Consumer Care AG, Basel 4052, Switzerland
  • 4Vytaderm, Fair Lawn, NJ 07410, USA
  • 5PEPITE (EA4267) University of Burgundy / Franche-Comté, Besançon 25000, France
  • 6Ferring Pharmaceuticals Inc, Parsippany, NJ 07054, USA

Abstract

5-amino salicylic acid (5-ASA) is a standard therapy for the treatment of mild to moderate forms of inflammatory bowel diseases (IBD) whereas more severe forms involve the use of steroids and immunosuppressive drugs. Hyaluronic acid (HA) is a naturally occurring non-sulfated glycosaminoglycan that has shown epithelium protective effects in experimental colitis recently. In this study, both 5-ASA (30 mg/kg) and HA (15 mg/kg or 30 mg/kg) were administered rectally and investigated for their potential complementary therapeutic effects in moderate or severe murine colitis models. Intrarectal treatment of moderate and severe colitis with 5-ASA alone or HA alone at a dose of 30 mg/kg led to a significant decrease in clinical activity and histology scores, myeloperoxidase activity (MPO), TNF-α, IL-6 and IL-1β in colitis mice compared to untreated animals. The combination of HA (30 mg/kg) and 5-ASA in severe colitis led to a significant improvement of colitis compared to 5-ASA alone. Combined rectal therapy with HA and 5-ASA could be a treatment alternative for severe cases of IBD as it was the only treatment tested that was not significantly different from the healthy control group. This study further underlines the benefit of searching for yet unexplored drug combinations that show therapeutic potential in IBD without the need of designing completely new drug entities.

Keyword

Hyaluronic acid; Inflammatory bowel disease; Colitis; Inflammation; 5-amino salicylic acid
Full Text Links
  • BT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr