Clin Exp Pediatr.  2021 Aug;64(8):384-392. 10.3345/cep.2020.00451.

Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants

  • 1Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea
  • 2Department of Pediatrics & Medical Science, Chungnam National University School of Medicine, Daejeon, Korea


Paroxysmal nonepileptic events (PNE) comprise of a variety of nonepileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by the caregiver. In infants, physiologic PNE accounts for the majority of the PNE. It is important to exclude epilepsy, for which blood tests, electroencephalography, and imaging tests can facilitate differential diagnosis. Since most PNE have a benign progress, symptoms often improve with age and without special treatment. Therefore, it is important to reassure the caregivers after making an accurate diagnosis.


Nonepileptic seizure; Seizure; Infant; Epilepsy; Electroencephalography
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