Korean J Transplant.  2021 Jun;35(2):86-92. 10.4285/kjt.21.0011.

Development of predictive score for posttransplant survival based on pre-transplant recipient characteristics

Affiliations
  • 1Department of Internal Medicine, Seongnam Citizens Medical Center, Seongnam, Korea
  • 2Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 3Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
  • 4Transplantation Center, Seoul National University Hospital, Seoul, Korea

Abstract

Background
The new kidney allocation system in the United States has introduced longevity matching, which gives priority to allocating the best quality organs to wait-listed candidates with the longest predicted survival for the efficient utilization of organs that are of limited availability. The estimated post-transplant survival (EPTS) score was developed in the United States to risk-stratify all wait-listed patients. However, prognostic indices used in Western countries were derived from data that may be different for Korea and do not necessarily reflect prognostic values for Korean deceased donor kidney transplantation. Prognostic indices for Korean wait-listed candidates therefore need to be developed from Korean data.
Methods
We analyzed 6,731 adult solitary kidney transplant patients for candidate risk prediction using the national data from the Korean Network for Organ Sharing (KONOS) and National Health Insurance Data Sharing Service (NHISS). Cox regression analysis was used to model the risk of patient death.
Results
The Korean EPTS (K-EPTS) score was developed based on four recipient parameters (age, diabetes mellitus, hepatitis C virus, and duration of dialysis) that showed a significant association with post-transplant survival. K-EPTS scores showed good discrimination (C-statistics: 0.690; 95% confidence interval, 0.666–0.715). Moreover, the ability of the K-EPTS score to discriminate patient survival was better than that of the EPTS according to the criteria of the United Network for Organ Sharing (US-EPTS) score (P<0.001).
Conclusions
The K-EPTS score, which was developed based on Korean national data, is expected to contribute to the assessment of recipient prognosis and efficient utilization of deceased donor kidneys.

Keyword

Kidney transplantation; Prognosis; Survival; Transplant recipient

Figure

  • Fig. 1 Study profile. DDKT, deceased donor kidney transplantation; BMI, body mass index.

  • Fig. 2 Patient survival in deceased donor kidney transplantation by US-EPTS or K-EPTS scores. (A) The lower US-EPTS score group (≤20%) showed a significant survival benefit as compared with the higher US-EPTS score group (>20%) (P<0.001). (B) The lower K-EPTS score group (≤20%) showed a significant survival benefit as compared with the higher K-EPTS score group (>20%) (P<0.001). US-EPTS, estimated post-transplant survival according to the criteria of the United Network for Organ Sharing; K-EPTS, Korean estimated post-transplant survival.


Reference

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