Korean J Fam Pract.  2021 Apr;11(2):135-141. 10.21215/kjfp.2021.11.2.135.

Association between Vitamin A, E and Type 2 Diabetes Mellitus in Korea: Korean National Health and Nutrition Examination Survey 2016–2018

Affiliations
  • 1Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
  • 2Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea

Abstract

Background
This study aimed to analyze the association of vitamins A and E with type 2 diabetes mellitus in Korea.
Methods
We used data from 3,596 individuals aged 45 years or older who participated in the vitamin test using the Korean National Health Examination and Nutrition Survey 2016–2018. The blood vitamin A and E concentrations equal to or above 0.70 and 20.0, which are upper normal limit, were classified as the fully sufficient group. An uncorrected analysis was conducted first, followed by adjustment for sex, age, income level, education level, marital status, BMI, hypertension, and dyslipidemia variables.
Results
For vitamin A, the difference in BMI, vitamin E, sex, high blood pressure, hyperlipidemia, and diabetes was significant, depending on whether it was the full adequate group or not. The full adequate group was significantly higher in BMI, vitamin E, males, high blood pressure, hyperlipidemia, and diabetes (BMI: 24.57 vs. 24.09, vitamin E: 16.81 vs. 14.04, hypertension: 42.0% vs. 32.7%, hyperlipidemia: 34.1% vs. 25.7%, diabetes: 20.9% vs. 15.2%). For vitamin E, differences in BMI, vitamin A, sex, and hyperlipidemia were significant, depending on whether a full adequate group was present. The full adequate group was significantly higher in BMI, vitamin A, females, and hyperlipidemia (BMI: 24.62 vs. 24.12, vitamin A: 0.65 vs. 0.54, hyperlipidemia: 34.5% vs. 26.3%). The probability of diabetes in the calibration model was significantly lower at 0.648 times than in non-vitamin E full estimate group cases (P<0.05).
Conclusion
We conclude that blood vitamin E levels and diabetes prevalence are correlated.

Keyword

Vitamin E; Blood Vitamin E Level; Diabetes Mellitus; Republic of Korea
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