Korean J Dent Mater.  2021 Mar;48(1):41-52. 10.14815/kjdm.2021.48.1.41.

Evaluation of the effect of vacuum heat treatment on the visible light remote-controlled drug release and antimicrobial activity of gold nanoparticle coated titania nanotubes

Affiliations
  • 1Department of Dental Biomaterials and the Institute of Biomaterials and Implant, Wonkwang University College of Dentistry, Iksan, Republic of Korea

Abstract

The purpose of this study was to evaluate the effect of vacuum heat treatment on the visible light remote-controlled drug release and consequent antimicrobial activity of gold nanoparticles coated on the surface of titania nanotubes. After the plasma coating of gold nanoparticles on a titania nanotube with a diameter of 100 nm, a homogeneously spherical gold shaped nanoparticle deposited on titania nanotube specimen was prepared through a vacuum heat treatment process. From the measurement of the diffuse reflective ultraviolet-visible-near-infrared spectrophotometer, the vacuum heated gold nanoparticles-titania nanotubes showed strong light absorption at the range of 400 to 650 nm. From the observation of field emission scanning electron microscopy, the size of the nanoparticles increased from 5.59±1.05 nm to 56.93±10.91 nm, and the aspect ratio also increased from 1.01±0.31 to 1.55±0.47, as the gold coating time increased from 1 minute to 9 minutes, respectively. From the results of antimicrobial drug elution test and the antibacterial test using Streptococcus mutans, before and after the visible light (wavelength 550 nm) irradiation of the antimicrobial drug (a polylactic acid containing 0.1% tetracycline) coated specimen, the drug elution value of the experimental group subjected to visible light irradiation was significantly higher than that of the control group without light irradiation (P<0.05). Also, significant antibacterial effect was evident in the experimental group subjected to visible light irradiation (P<0.05). Therefore, the study concluded that there is a possibility as an antimicrobial implant material with a visible light remote control drug elution function with the surface treatment technology of gold nanoparticles-titania nanotubes spheroidized using vacuum heat treatment.

Keyword

Gold nanoparticle; Titania nanotube; Vacuum heat-treatment; Visible light remote control; Antimicrobial effect
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