Int Neurourol J.  2021 Mar;25(1):12-22. 10.5213/inj.2040234.117.

Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms

  • 1Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Korea
  • 2Department of Urology, Jeonbuk National University Medical School, Jeonju, Korea
  • 3Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Korea
  • 4Institute of Health Sciences, Gyeongsang National University, Jinju, Korea


Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased which is defined as decreased ability of the testes to produce sperm and sex steroids because of a pituitary/hypothalamic, or testicular deficiency. In academic andrology associations, the term “male hypogonadism” is commonly used to categorize testosterone deficiency. Testosterone deficiency syndrome (TDS) is defined as a decrease in serum testosterone accompanied by symptoms such as libido decrease, depressive disorder, erectile dysfunction, and fatigue. Although the mechanism about testosterone-replacement therapy (TRT) effects on men with hypogonadism is not yet identified, TRT has been shown to effectively relieve the symptoms of TDS as well as LUTS by several studies. Although the present review demonstrates the effectiveness and safety of TRT in men with TDS by prior studies, future large scale of clinical trials should be conducted to present more high-quality evidence to clinicians and patients.


Androgens; Benign prostatic hyperplasia; Hypogonadism; Lower urinary tract symptoms; Testosterone
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