Immune Netw.  2021 Feb;21(1):e6. 10.4110/in.2021.21.e6.

Adenovirus Vectors: Excellent Tools for Vaccine Development

  • 1Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea


Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirusbased vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.


Adenovirus; Genetic vector; Adenovector; Vaccine
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