Biomol Ther.  2021 Mar;29(2):220-226. 10.4062/biomolther.2020.106.

Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging

• Kim YJ
• Lee JE
• Jang HS
• Hong SY
• Lee JB
• Park SY
• Hwang JS

• KMID: 2513490
• DOI: http://doi.org/10.4062/biomolther.2020.106

Abstract

The role of particulate matter (PM) in health problems including cardiovascular diseases (CVD) and pneumonia is becoming increasingly clear. Polycyclic aromatic hydrocarbons, major components of PM, bind to aryl hydrocarbon receptor (AhRs) and promote the expression of CYP1A1 through the AhR pathway in keratinocytes. Activation of AhRs in skin cells is associated with cell differentiation in keratinocytes and inflammation, resulting in dermatological lesions. Oleanolic acid, a natural component of L. lucidum, also has anti-inflammation, anticancer, and antioxidant characteristics. Previously, we found that PM _10, induced the AhR signaling pathway and autophagy process in keratinocytes. Here, we investigated the effects of oleanolic acid on PM _10,-induced skin aging. We observed that oleanolic acid inhibits PM _10,-induced CYP1A1 and decreases the increase of tumor necrosis factor– alpha and interleukin 6 induced by PM _10,. A supernatant derived from keratinocytes cotreated with oleanolic acid and PM _10, inhibited the release of matrix metalloproteinase 1 in dermal fibroblasts. Also, the AhR-mediated autophagy disruption was recovered by oleanolic acid. Thus, oleanolic acid may be a potential treatment for addressing PM _10,-induced skin aging.

Keyword

PM; AhR; Oleanolic acid; TNF-α MMP-1; Autophagy