J Korean Ophthalmol Soc.  2021 Feb;62(2):184-192. 10.3341/jkos.2021.62.2.184.

A Comparison of Central Corneal Thickness Measurements and Measurement Repeatability Using Three Imaging Modalities

Affiliations
  • 1Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea

Abstract

Purpose
To compare and analyze central corneal thickness (CCT) measurements and measurement repeatability according to the corneal thickness obtained with anterior segment optical coherence tomography (AS-OCT), ultrasound pachymetry (USP), and dual Scheimpflug imaging (Galilei G4®).
Methods
CCT measurements obtained using AS-OCT, USP, and a dual rotating Scheimpflug camera in 120 eyes of 60 healthy subjects were compared and the repeatability was analyzed.
Results
The average CCT measurements using AS-OCT, USP, and a dual rotating Scheimpflug camera were 511.23 ± 37.16, 525.78 ± 39.22, and 531.43 ± 41.57 μm, respectively. The CCT measurement using dual rotating Scheimpflug imaging was statistically significantly thicker than that measured using AS-OCT (p < 0.05). A significant linear correlation was observed among OCT, USP, and dual rotating Scheimpflug measurements (r > 0.900, p < 0.001). All three methods showed high repeatability (intraclass correlation coefficient ≥ 0.996) for intra-examiner CCT measurements.
Conclusions
The CCT measurement results using the three methods were significantly correlated and showed high repeatability. However, the AS-OCT measurement was significantly thinner than that obtained using a dual rotating Scheimpflug camera. CCT measurement with a dual rotating Scheimpflug camera is a better alternative for USP than AS-OCT. Therefore, CCT should be interpreted in the context of the instrument used.

Keyword

Anterior segment optical coherence tomography, Central corneal thickness, Dual rotating Scheimpflug camera, Ultrasound pachymetry
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