Ann Lab Med.  2021 May;41(3):342-345. 10.3343/alm.2021.41.3.342.

LSAMP Rearrangement in Acute Myeloid Leukemia With a Jumping Translocation Involving 3q13.31

Affiliations
  • 1Department of Laboratory Medicine, Korea University Guro Hospital, Seoul, Korea
  • 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 3Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea
  • 4Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea


Figure

  • Fig. 1 G-banding karyotype. Closed arrows indicate the JT breakpoints at each derivative chromosome. Karyotype showing (A) trisomy 8 and der(12)t(3;12)(q13.3;q24.3), (B) trisomy 8 and der(13)t(3;13)(q13.3;p13), and (C) trisomy 8 and der(18) t(3;18)(q13.3;p11.3). (D) Partial karyotype showing the JT in-volving 3q13.3. Abbreviation: JT, jumping translocation.

  • Fig. 2 The fusion transcript of the JT involving 3q13.3 identified by RNA-sequencing analysis and Sanger sequencing. (A) Chromosomal array demonstrating the breakpoints corresponding to an interstitial deletion of 3q13.31 and a gain in 3q13.32-q29. (B) Partial sequences surrounding LSAMP and the intergenic region fusion showing the junction of LSAMP exon 1 and the intergenic region (chr3:117,716,029). (C) Schematic diagrams of genomic breakpoints mapped with blue and red arrows indicating each breakpoint. The thick blue boxes represent the coding exon and 5´ untranslated region. The thin red line represents the DNA introns and intergenic regions. Abbreviation: JT, jumping translocation.


Reference

1. Berger R, Bernard OA. 2007; Jumping translocations. Genes Chromosomes Cancer. 46:717–23. DOI: 10.1002/gcc.20456. PMID: 17444494.
Article
2. Kjeldsen E. 2017; Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia. Exp Mol Pathol. 103:14–25. DOI: 10.1016/j.yexmp.2017.06.002. PMID: 28625614.
Article
3. Bernard M, Lemée F, Picard F, Ghandour C, Drenou B, Le Prise PY, et al. 2000; Jumping translocation in acute leukemia of myelomonocytic lineage: a case report and review of the literature. Leukemia. 14:119–22. DOI: 10.1038/sj.leu.2401637. PMID: 10637486.
Article
4. Reis MD, Dubé ID, Pinkerton PH, Chen-Lai J, Robinson JB, Klock RJ, et al. 1991; "Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia. Cancer Genet Cytogenet. 51:189–94. DOI: 10.1016/0165-4608(91)90131-D. PMID: 1993304.
Article
5. Shin SY, Lee ST, Kim HJ, Cho EH, Kim JW, Park S, et al. 2016; Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations. Oncotarget. 23:54825–37. DOI: 10.18632/oncotarget.10240. PMID: 27359055. PMCID: PMC5342384.
6. Hatakeyama S, Osawa M, Omine M, Ishikawa F. 1999; JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. Oncogene. 18:2085–90. DOI: 10.1038/sj.onc.1202510. PMID: 10321732.
Article
7. Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, et al. 2003; The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell. 4:405–13. DOI: 10.1016/S1535-6108(03)00269-1. PMID: 14667507.
8. Ntougkos E, Rush R, Scott D, Frankenberg T, Gabra H, Smyth JF, et al. 2005; The IgLON family in epithelial ovarian cancer: expression profiles and clinicopathologic correlates. Clin Cancer Res. 11:5764–8. DOI: 10.1158/1078-0432.CCR-04-2388. PMID: 16115914.
Article
9. Yen CC, Chen WM, Chen TH, Chen WY, Chen PC, Chiou HJ, et al. 2009; Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. Int J Oncol. 35:775–88. DOI: 10.3892/ijo_00000390. PMID: 19724913.
Article
10. Petrovics G, Li H, Stümpel T, Tan SH, Young D, Katta S, et al. 2015; A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men. EBioMedicine. 2:1957–64. DOI: 10.1016/j.ebiom.2015.10.028. PMID: 26844274. PMCID: PMC4703707.
Full Text Links
  • ALM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr