Yeungnam Univ J Med.  2021 Jan;38(1):47-52. 10.12701/yujm.2020.00325.

Evaluation of craniofacial morphology in short-statured children: growth hormone deficiency versus idiopathic short stature

Affiliations
  • 1Department of Dentistry, Yeungnam University College of Medicine, Daegu, Korea
  • 2Department of Dental Hygiene, College of Science and Technology, Kyungpook National University, Sangju, Korea
  • 3Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea
  • 4Department of Dentistry, Yeungnam University Hospital, Daegu, Korea

Abstract

Background
Short stature is defined as a height below the 3rd percentile or more than two standard deviations below the mean for a given age, sex, and population. There have been inconsistent results regarding craniofacial morphology in short-statured children. This study aimed to analyze the differences between short-statured children with growth hormone deficiency, idiopathic short-statured children, and normal children.
Methods
Thirty-one short-statured children with growth hormone deficiency, 32 idiopathic short-statured children, and 32 healthy children were enrolled in this study. The measurements of their craniofacial structures from lateral cephalograms were evaluated.
Results
There were statistically significant differences among the three groups seven variables (anterior cranial base length, posterior cranial base length, total cranial base length, upper posterior facial height, posterior total facial height, mandibular ramus length, and overall mandibular length) in the linear measurement and five variables (saddle angle, gonial angle, mandibular plane angle, position of mandible, and maxilla versus mandible) in the angular measurement.
Conclusion
Compared to the control group, many linear and angular measurements of the craniofacial structures were significantly different in the two short-statured groups (p<0.05). Treatment plans by orthodontists should include these craniofacial structure characteristics.

Keyword

Child; Growth; Mandible; Maxilla; Orthodontists

Figure

  • Fig. 1. Cephalometric landmarks. S, sella; N, nasion; Ba, basion; Art, articulare; PNS, posterior nasal spine; ANS, anterior nasal spine; Go, gonion; A, subspinale; B, supraentale; Pog, pogonion; Me, menton; Gn, gnathion.


Reference

References

1. Herpin N. Le pouvoir des grands: de l’influence de la taille des hommes sur leur statut social. Paris: Découverte;2006.
2. You JB. “My son should be 175cm and daughter 165cm or more”… Parents worry about discrimination [Internet]. Jung-Ang Ilbo;2020. Oct. 21. [cited 2020 Jun 10]. https://news.joins.com/article/18905427.
3. Barstow C, Rerucha C. Evaluation of short and tall stature in children. Am Fam Physician. 2015; 92:43–50.
4. Cox LA. The biology of bone maturation and ageing. Acta Paediatr Suppl. 1997; 423:107–8.
Article
5. Cao F, Huang HK, Pietka E, Gilsanz V. Digital hand atlas and web-based bone age assessment: system design and implementation. Comput Med Imaging Graph. 2000; 24:297–307.
Article
6. Bilgili Y, Hizel S, Kara SA, Sanli C, Erdal HH, Altinok D. Accuracy of skeletal age assessment in children from birth to 6 years of age with the ultrasonographic version of the Greulich-Pyle atlas. J Ultrasound Med. 2003; 22:683–90.
Article
7. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. 1994; 125:29–35.
Article
8. Grote FK, Oostdijk W, De Muinck Keizer-Schrama SM, van Dommelen P, van Buuren S, Dekker FW, et al. The diagnostic work up of growth failure in secondary health care; an evaluation of consensus guidelines. BMC Pediatr. 2008; 8:21.
Article
9. Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014; 30:858–61.
10. Spiegel RN, Sather AH, Hayles AB. Cephalometric study of children with various endocrine diseases. Am J Orthod. 1971; 59:362–75.
Article
11. Konfino R, Pertzelan A, Laron Z. Cephalometric measurements of familial dwarfism and high plasma immunoreactive growth hormone. Am J Orthod. 1975; 68:196–201.
Article
12. Cantu G, Buschang PH, Gonzalez JL. Differential growth and maturation in idiopathic growth-hormone-deficient children. Eur J Orthod. 1997; 19:131–9.
Article
13. Kjellberg H, Beiring M, Albertsson Wikland K. Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency. Eur J Oral Sci. 2000; 108:359–67.
Article
14. Partyka M, Dunin-Wilczyńska I, Chałas R. Disorders of the stomatognathic system in patients with short stature. Pol Merkur Lekarski. 2014; 36:63–7.
15. Broadbent BH Sr, Broadbent BH Jr, Golden WH. Bolton standards of dentofacial development growth. St. Louis: CV Mosby;1975.
16. Pirinen S, Majurin A, Lenko HL, Koski K. Craniofacial features in patients with deficient and excessive growth hormone. J Craniofac Genet Dev Biol. 1994; 14:144–52.
17. Thilander B. Basic mechanisms in craniofacial growth. Acta Odontol Scand. 1995; 53:144–51.
Article
18. Nanda RS. The rate of growth of several facial components measured from serial cephalometric roentgenograms. Am J Orthod. 1955; 41:658–73.
19. Björk A, Helm S. Prediction of the age of maximum puberal growth in body height. Angle Orthod. 1967; 37:134–43.
20. Baughan B, Demirjian A, Levesque GY, Lapalme-Chaput L. The pattern of facial growth before and during puberty, as shown by French-Canadian girls. Ann Hum Biol. 1979; 6:59–76.
Article
21. Chung SH, Kim JW, Park YH, Hwang CJ, Lee HK. The effect of growth hormone treatment on craniofacial growth in short stature children. Korean J Orthod. 2010; 40:227–38.
Article
22. Van Erum R, Mulier M, Carels C, de Zegher F. Short stature of prenatal origin: craniofacial growth and dental maturation. Eur J Orthod. 1998; 20:417–25.
Article
23. Poole AE, Greene IM, Buschang PH. The effect of growth hormone therapy on longitudinal growth of the oral facial structures in children. Prog Clin Biol Res. 1982; 101:499–516.
24. Grimberg A, Kutikov JK, Cucchiara AJ. Sex differences in patients referred for evaluation of poor growth. J Pediatr. 2005; 146:212–6.
Article
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