J Gynecol Oncol.  2020 Nov;31(6):e81. 10.3802/jgo.2020.31.e81.

Uterine clear cell carcinoma risk in White versus non-White US subpopulations: does race matter?

  • 1Division of Gynecologic Oncology, Stanford University Medical Center, Stanford, CA, USA
  • 2Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA
  • 3Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
  • 4Division of Gynecologic Oncology, Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA
  • 5Gynecologic Cancer Center of Excellence, Department of Obstetrics & Gynecology, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD, USA
  • 6The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
  • 7John P Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, MD, USA
  • 8Division of Gynecologic Oncology, Palo Alto Medical Foundation, California Pacific Medical Center, Sutter Health, San Francisco, CA, USA


To determine incidence rates of uterine clear cell carcinoma among non-White US subpopulations.
Data from the United States Cancer Statistics and National Cancer Database from 2004 to 2016 were analyzed using descriptive statistics.
A total of 488,811 women were diagnosed with uterine cancer from 2004–2016. Of these, 73.3% were endometrioid, 6.6% were serous, 5.3% were carcinosarcoma, 1.4% were clear cell, and 13.4% were other. Blacks had the highest incidence rate of uterine clear cell compared with Whites, Asian/Pacific Islanders, and American Indian/Alaska Natives (0.59 vs. 0.31, 0.29, and 0.24, respectively). Overall mean age at diagnosis was 68.6 years, with the youngest age in Asian/Pacific Islanders compared to Whites, Blacks, and American Indian/Alaska Natives (65.9 vs. 68.7, 68.6, and 66.3 years, respectively). Analysis of the Asian subpopulation revealed significantly younger age at diagnosis in Vietnamese women (55.8 years) compared with 72.4 years in Japanese, 68.6 years in Pacific Islander, 66.6 years in Indian/Pakistani, 65.9 years in Filipino, 65.8 years in Chinese, 65.2 years in Korean, and 63.7 years in other Asians.
Black women are two times more likely to be diagnosed with uterine clear cell carcinoma compared with other races. Asians present at younger ages, with Vietnamese women most likely to be diagnosed at the youngest age.


Adenocarcinoma; Clear Cell; Uterine Neoplasms; African Americans; Asian Americans; Incidence; Ethnic Groups
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