Maxillofac Plast Reconstr Surg.  2020;42(1):30. 10.1186/s40902-020-00274-3.

Association of maxillary dental developmental abnormality with precocious puberty: a case-control study

  • 1Department of Preventive Dentistry and Public Oral Health, Yonsei University, Seoul, Korea
  • 2Department of Orthodontics, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam-si, Korea
  • 3Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam-si, Korea
  • 4Department of Oral and Maxillofacial Surgery, Section of Dentistry, Armed Forces Medical Command, Armed Forces Capital Dental Hospital, Seongnam-si, 13634, Korea
  • 5Department of Oral and Maxillofacial Surgery, Seoul Asan Medical Center, Seoul, Korea
  • 6Department of Biostatistics, Korea University College of Medicine, Seoul, Korea


Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs).
This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively.
Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP.
Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.


Dental developmental abnormality; Gonadotropin-releasing hormone; Mesiodens; Precocious puberty; Supernumerary tooth
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