Clin Exp Vaccine Res.  2020 Jul;9(2):174-178. 10.7774/cevr.2020.9.2.174.

Potential use of 3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride as an antimicrobial and antiviral agent for the disinfection of personal protective equipment

Affiliations
  • 1College of Veterinary Medicine, Konkuk University, Seoul, Korea
  • 2Konkuk Ctc Bio Animal Vaccine Co. Ltd., Seoul, Korea

Abstract

Currently, no vaccine or established therapeutic agents are available for coronavirus disease 2019. The sharp increase in demand for personal protective equipment (PPE) necessitates an improvement in the protective efficacy of PPE. We evaluated the potential antimicrobial and antiviral effects of a surface-coating disinfectant (3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride, Si-QAC) when applied onto PPE. Si-QAC-pre-coated PPE was artificially contaminated with either influenza virus or Salmonella. The results showed significantly reduced influenza and Salmonella titers in Si-QAC-coated PPE; these antimicrobial effects lasted 7 days. This suggests that this surface-coating disinfectant effectively reduces pathogen contamination of PPE, enabling their safe and long-term use.

Keyword

Coating disinfectant; Si-QAC; Antimicrobial; Antiviral; Long-lasting
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