Cancer Res Treat.  2021 Jan;53(1):140-147. 10.4143/crt.2020.480.

Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study

Affiliations
  • 1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 2Cancer Research Institute, Seoul National University, Seoul, Korea
  • 3Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea
  • 4JW LEE Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 5Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 6Seoul Center for Infectious Disease Control, Seoul, Korea

Abstract

Purpose
Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries.
Materials and Methods
The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders.
Results
In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45).
Conclusion
Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.

Keyword

Colorectal neoplasms; Korea; Calcium intake; Recommended intake of calcium
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