J Dig Cancer Rep.  2020 Dec;8(2):77-80.

Aspirin and Non-steroidal Anti-inflammatory Drugs in Prevention of Gastric Cancer

  • 1Department of Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea


Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A number of recent studies have been published evaluating the chemopreventive effect of aspirin and non steroidal anti inflammatory drungs (NSAIDs) against gastric cancer. Aspirin and NSAIDs use may reduce the risk of gastric cancer incidence and death, whereas other studies have reported contradictory results. Therefore, further study should be needed to clarify the role of aspirin and NSAIDs in the chemoprevention of gastric cancer.


Anti-inflammatory agents; Non-steroidal; Aspirin; Chemoprevention; Low-dose; Stomach neoplasia
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