World J Mens Health.  2021 Jan;39(1):19-30. 10.5534/wjmh.190167.

Oxidative Stress, Nutrition and Cancer: Friends or Foes?

Affiliations
  • 1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

Abstract

The relationship between cancer and nutrition, as well as nutrition and oxidative stress, shares puzzling aspects that current research is investigating as the possible components of an intriguing regulating mechanism involving the complex interplay between adipose tissue and other compartments. Along the very recent biological evolution, humans underwent a rapid change in their lifestyles and henceforth the role of the adipocytes earned a much more complex task in the fine tuning of the tissue microenvironment. A lipidic signaling language probably evolved in association with the signaling role of reactive oxygen species, which gained a fundamental part in the regulation of cell stem and plasticity. The possible relationship with cancer onset might have some causative mechanism in the impairment of this complex task, usually deregulated by drastic changes in one’s own lifestyle and dietary habit. This review tries to address this issue.

Keyword

Adipose tissue; Cancer; Lifestyle; Oxidative stress; Redox
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