Korean J Med.
2020 Dec;95(6):404-408. 10.3904/kjm.2020.95.6.404.
Acute Kidney Injury after Administering Dapagliflozin to a Diabetic Patient with Acute Cerebral Infarction
- Affiliations
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- 1Division of Nephrology, Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea
- 2Department of Internal Medicine, Baek-jae General Hospital, Nonsan, Korea
- 3Department of Internal Medicine, Daejeon Chamsarang Convalescent Hospital, Daejeon, Korea
- KMID: 2509487
- DOI: http://doi.org/10.3904/kjm.2020.95.6.404
Abstract
- Dapagliflozin is a recently developed oral anti-diabetic drug and SGLT2 inhibitor with well-known cardioprotective and renoprotective effects. Although a reduction of the glomerular filtration rate is induced by volume depletion and tubule-glomerular feedback during the early period after administering a SGLT2 inhibitor, the renal prognosis improves more with a decrease of proteinuria. However, the risk of acute kidney injury increases in heart failure and hypovolemia patients, and in those taking certain drugs, such as non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers, or diuretics. We report acute kidney injury after dapagliflozin administration in a diabetic patient with acute cerebral infarction accompanied by right hemiplegia, motor aphasia, and dysphagia.
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