Korean J Transplant.  2020 Dec;34(Supple 1):S189. 10.4285/ATW2020.PO-1023.

Outcome of ABO-incompatible kidney transplantation depending on the ABO type of transfused plasma: comparative analysis between the universal AB plasma and donor type plasma

Affiliations
  • 1Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea
  • 3Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea
  • 4Division of Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Abstract

Background
Since the remarkable development of various desensitization methods and immunosuppressive agents, the outcome of ABO-incompatible solid organ transplantation has greatly improved. However, there is no evidence-based consensus about how to determine the blood type of blood products for transfusion to recipients of ABO-incompatible solid organ transplantation, and each institution has its own principles.
Methods
We retrospectively analyzed the data of 60 ABO-incompatible kidney transplantation recipients between August 2009 and June 2013. All recipients had blood type O, and their donors’ blood type was A or B. Patients’ demographics and clinical status were compared between the two recipient groups; one group received AB plasma despite the donor’s blood type (n=30), and the other group received plasma that matched the donor’s blood type (n=30). 
Results
The demographics of the two groups did not show statistically significant differences. Both rejection-free survival and rejection rate graphs seemed favorable in the group that received donor type plasma, but no statistically significant difference was observed. Other parameters did not show significant differences.
Conclusions
We suggest a strategy for transfusion in ABO-incompatible solid organ transplantation. This strategy can improve transfusion safety and the efficient use of blood products.

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