Infect Chemother.  2020 Mar;52(1):19-30. 10.3947/ic.2020.52.1.19.

Antimicrobial Therapy and Antimicrobial Stewardship in Sepsis

  • 1Division of Infectious Diseases, Korea University Medicine, Korea University Ansan Hospital, Ansan, Korea


Since sepsis was first defined, sepsis management has remained challenging. To improve mortality rates for sepsis and septic shock, an accurate diagnosis and prompt administration of appropriate antibiotics are essential. The goals of antimicrobial stewardship are to achieve optimal clinical outcomes and to ensure cost-effectiveness and minimal unintended consequences, such as toxic effects and development of resistant pathogens. A combination of inadequate diagnostic criteria for sepsis and time pressure to provide broad-spectrum antimicrobial therapy remains an obstacle for antimicrobial stewardship. Efforts such as selection of appropriate empirical antibiotics and de-escalation or determination of whether or not to stop antibiotics may help to improve a patient's clinical prognosis as well as the successful implementation of antimicrobial stewardship.


Sepsis; Septic shock; Antibiotics; Antimicrobial stewardship
Full Text Links
  • IC
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: