J Korean Diabetes.  2020 Sep;21(3):120-125. 10.4093/jkd.2020.21.3.120.

Management of Diabetes in Coronavirus Disease 2019: Prognosis and Practical Issues

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea

Abstract

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic by the World Health Organization on March 11, 2020. COVID-19 pandemic emphasizes the importance of understanding the pathophysiology which can potentially influence the treatment choices of people with chronic disease such as type 2 diabetes. The reasons for worse prognosis with COVID-19 in people with diabetes include age, sex, ethnicity, comorbidities such as hypertension, cardiovascular disease, obesity and a proinflammatory status. Medications for glucose-lowering and antihypertensive agents should be carefully assessed which can modulate the risk or may have potential interactions with SARS-CoV-2. It is also important to note that SARS-CoV-2 may exacerbate glucose metabolism through direct beta-cell damage, leading to acute hyperglycemic complications and potential new onset diabetes.

Keyword

Coronavirus disease 2019; Severe acute respiratory syndrome coronavirus 2; Type 2 diabetes
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