Korean J Pain.  2020 Jan;33(1):54-59. 10.3344/kjp.2020.33.1.54.

The prognostic value of median nerve thickness in diagnosing carpal tunnel syndrome using magnetic resonance imaging: a pilot study

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Anesthesiology and Pain Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea
  • 3Department of Anesthesiology and Pain Medicine, Catholic Kwandong University International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea

Abstract

Background
The median nerve cross-sectional area (MNCSA) is a useful morphological parameter for the evaluation of carpal tunnel syndrome (CTS). However, there have been limited studies investigating the anatomical basis of median nerve flattening. Thus, to evaluate the connection between median nerve flattening and CTS, we carried out a measurement of the median nerve thickness (MNT).
Methods
Both MNCSA and MNT measurement tools were collected from 20 patients with CTS, and from 20 control individuals who underwent carpal tunnel magnetic resonance imaging (CTMRI). We measured the MNCSA and MNT at the level of the hook of hamate on CTMRI. The MNCSA was measured on the transverse angled sections through the whole area. The MNT was measured based on the most compressed MNT.
Results
The mean MNCSA was 9.01 ± 1.94 mm 2 in the control group and 6.58 ± 1.75 mm 2 in the CTS group. The mean MNT was 2.18 ± 0.39 mm in the control group and 1.43 ± 0.28 mm in the CTS group. Receiver operating characteristics curve analysis demonstrated that the optimal cut-off value for the MNCSA was 7.72 mm2 , with 75.0% sensitivity, 75.0% specificity, and an area under the curve (AUC) of 0.82 (95% confidence interval [CI], 0.69-0.95). The best cut off-threshold of the MNT was 1.76 mm, with 85% sensitivity, 85% specificity, and an AUC of 0.94 (95% CI, 0.87-1.00).
Conclusions
Even though both MNCSA and MNT were significantly associated with CTS, MNT was identified as a more suitable measurement parameter.

Keyword

Anatomy; Area Under Curve; Carpal Tunnel Syndrome; Diagnosis; Hamate Bone; Magnetic Resonance Imaging; Median Nerve; ROC Curve; Wrist

Figure

  • Fig. 1 Axial T1-weighted carpal tunnel magnetic resonance imagings of the median nerve cross-sectional area (MNCSA) (A) and median nerve thickness (MNT) (B) at the hook of hamate level.

  • Fig. 2 Receiver operating characteristic curve of the median nerve thickness (MNT) and median nerve cross-sectional area (MNCSA) for prediction of carpal tunnel syndrome. The most suitable cut-off point of MNT was 1.76 mm vs. 7.49 mm2 of MNCSA, with sensitivity 85% vs. 80%, specificity 85% vs. 80% and an area under the curve 0.94 vs. 0.82, respectively.


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