Korean J Urol Oncol.  2020 Aug;18(2):78-90. 10.22465/kjuo.2020.18.2.78.

Epigenetic Approaches to the Treatment of Renal Cell Cancer

  • 1Department of Urology, Hanyang University College of Medicine, Seoul, Korea
  • 2Department of Translational Medicine, Hanyang University Graduate School for Biomedical Science & Engineering, Seoul, Korea


To summarize the epigenetics in renal cell carcinoma (RCC) and discuss the potential use of epigenetic modifiersas RCC biomarkers and treatments. Pertinent articles available on PubMed and google scholar database pertainingto kidney cancer and epigenetics were reviewed. Metastatic RCC is one of the most difficult cancers to treat.Although RCC is commonly known to be caused by VHL mutations, it is not enough to understand the completepathophysiology of RCC. Epigenetic factors can play a fundamental role in the pathogenesis of RCC. Epigeneticregulators are classified as epigenetic writers, readers, and erasers according to their role. In this review, wediscuss the potential role of epigenetic regulators as a biomarker for RCC. We also review medications thattarget epigenetic enzymes and are currently tried in RCC therapy.


Epigenetics; Kidney cancer
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