J Korean Med Sci.  2020 Aug;35(34):e296. 10.3346/jkms.2020.35.e296.

Association of Self-Reported and Cotinine-Verified Smoking Status with Atrial Arrhythmia

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

Background
The relationship between self-reported and urinary cotinine-verified smoking status and atrial arrhythmia (AA) is unclear. The aim of this study was to evaluate the association of self-reported and urine cotinine-verified smoking status with AA. Method: A total of 201,788 participants (106,375 men, mean age 37 years) who had both a urinary cotinine measurement and electrocardiogram were included. Cotinine-verified current smoking was defined as a urinary cotinine level above 50 ng/mL. Individuals were divided into three groups based on self-reported smoking and two groups based on cotinineverified smoking status.
Results
Among overall subjects, 505 had documented AA (0.3%) and 135 had atrial fibrillation (AF) (0.1%). Self-reported current smoking was associated with an increased risk of AA (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.06–1.91; p = 0.019) and AF (OR, 2.20; 95% CI, 1.24–3.90; p = 0.007), whereas self-reported former smoking had no significant association with AA (OR, 1.30; 95% CI, 0.97–1.73; p = 0.078) and AF (OR, 1.74; 95% CI, 1.00–3.04; p = 0.051). Cotinine-verified current smoking showed no significant association with AA (OR, 1.24; 95% CI, 0.98–1.58; p = 0.080) and AF (OR, 1.20; 95% CI, 0.79–1.83; p = 0.391).
Conclusion
Self-reported current smoking was associated with AA and AF, while selfreported former smoking and cotinine-verified current smoking showed no significant association with AA and AF.

Keyword

Cigarette Smoking; Arrhythmias; Cotinine; Nicotine
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