J Korean Assoc Oral Maxillofac Surg.  2020 Aug;46(4):288-291. 10.5125/jkaoms.2020.46.4.288.

Radiation-induced angiosarcoma (RIAS) of the maxilla: a case report

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea
  • 2Department of Radiation Oncology, Dankook University College of Medicine, Cheonan, Korea

Abstract

Angiosarcoma is a rare malignant mesenchymal tumor of vascular or lymphatic origin and represents less than 1% of all malignant tumors. Radiation therapy is a standard treatment in many head and neck cancer cases, but ionizing radiation is associated with radiation carcinogenesis including radiation-induced angiosarcoma. In this article, we report a rare case of radiation-induced angiosarcoma found in a 58-year-old female patient who was previously diagnosed with an odontogenic keratocyst and mucoepidermoid carcinoma.

Keyword

Radiation-induced angiosarcoma; Radiation carcinogenesis; Mucoepidermoid carcinoma; Odontogenic keratocyst; Angiosarcoma

Figure

  • Fig. 1 Proton emission tomography-computed tomography showing hypermetabolic lesion around right maxilla and nasal cavity.

  • Fig. 2 A. Preoperative photograph of angiosarcoma in palate. B. Postoperative photograph of angiosarcoma in palate after resection.

  • Fig. 3 A. Most of the cells show atypical spindle shape with hyperchromatic nuclei (H&E staining, ×200). B. This area shows vascular formation (H&E staining, ×200).

  • Fig. 4 A. The tumor cells are strongly positive for FLI-1 (×200). B. The tumor cells are strongly positive for INI-1 (×200).


Reference

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