J Korean Ophthalmol Soc.  2020 Aug;61(8):868-875. 10.3341/jkos.2020.61.8.868.

Anti-staphylococcal Effect of a Nephrite-containing Contact Lens Storage Case

Affiliations
  • 1Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
  • 2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
  • 3Department of Ophthalmology, Kosin University College of Medicine, Busan, Korea
  • 4Department of Optometry, Busan Women’s College, Busan, Korea
  • 5ent of Parasitology and Tropical Medicine, Pusan National University School of Medicine, Yangsan, Korea

Abstract

Purpose
To compare the anti-staphylococcal effect of nephrite-containing contact lens (CL) storage cases and conventional CLstorage cases. Method: The degree of proliferation and adhesion of Staphylococcus aureus (S. aureus) on first- to third-generation silicone hydrogelcontact lenses (SHCLs) was analyzed through comparison of 5% nephrite-containing CL storage cases and conventionalCL storage cases. The degree of adhesion of S. aureus to the CL was also compared between 1% or 5% nephrite solution andmultipurpose solution (MPS). Result: Nephrite-containing CL storage cases showed a significant inhibitory effect on S. aureus proliferation (p = 0.004) and significantlyreduced the number of adherent S. aureus on all first- to third generation SHCLs compared with conventional CL storagecases (p = 0.026, p = 0.043, and p = 0.001, respectively). The anti-staphylococcal effect of 1% and 5% nephrite solutionswas not significantly better than that of MPS.
Conclusions
Nephrite shows potential as a next-generation substance for reducing infectious keratitis caused by S. aureuswhen added to CL storage cases.

Keyword

Contact lens storage case; Infectious keratitis; Multipurpose solution; Nephrite; Staphylococcus aureus
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