Int J Stem Cells.  2020 Jul;13(2):237-245. 10.15283/ijsc20001.

SOCS1 Regulates the Immunomodulatory Roles of MSCs on B Cells

  • 1Animal Physiology Laboratory, School of Agroforestry Engineering and Planning, Tongren University, Tongren, China
  • 2Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing, China
  • 3Department of Anatomy, School of Basic Medical Sciences, Xiangnan University, Chenzhou, China
  • 4Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China
  • 5Laboratory of Animal Genetic Breeding and Reproduction, Yanbian University, Yanji, China


Background and Objective
s: The effective use of MSCs for the treatment of some B cell-mediated immune diseases is quite limited. The main reason is that the immunomodulatory effects of mesenchymal stem cells (MSCs) on B cells are unclear, and their underlying mechanisms have not been fully explored.
Methods and Results
By co-culturing B cells with MSCs without (MSC/CTLsh) or with suppressor of cytokine signaling 1 (SOCS1) knockdown (MSC/SOCS1sh), we found that MSCs inhibited B cell proliferation, activation and terminal differentiation. Remarkably, the highest inhibition of B cell proliferation was observed in MSC/SOCS1sh co-culture. Besides, MSC/SOCS1sh reversed the inhibitory effect of MSCs in the last stage of B cell differentiation. However, MSC/SOCS1sh had no effect on inhibiting B cell activation by MSCs. We also showed that IgA+ B cell production was significantly higher in MSC/SOCS1sh than in MSC/CTLsh, although no difference was observed when both MSCs co-cultures were compared to isolated B cells. In addition, MSCs increased PGE2 production after TNF-α/IFN-γ stimulation, with the highest increase observed in MSC/SOCS1sh co-culture.
Our results highlighted the role of SOCS1 as an important new mediator in the regulation of B cell function by MSCs. Therefore, these data may help to develop new treatments for B cell-mediated immune diseases.


MSCs immunomodulation; SOCS1; B cell
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