Lab Med Online.  2020 Jul;10(3):202-206. 10.3343/lmo.2020.10.3.202.

Performance Evaluation of the ABL90 FLEX PLUS Point-of-Care Analyzer in Measuring Creatinine Levels

  • 1Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
  • 2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea


To diagnose acute renal failure, creatinine levels in whole blood are typically assessed using point-of-care testing (POCT) methods. The present study aimed to evaluate the performance of a newly developed POCT blood gas analyzer, the ABL90 FLEX PLUS (Radiometer, Denmark), which can measure creatinine in blood.
Precision and linearity of the ABL90 FLEX PLUS were evaluated and compared with those of the Beckman Coulter AU5800 (Beckman Coulter, USA), according to the CLSI guidelines for creatinine measurement performance.
For the ABL90 FLEX PLUS, the total imprecision (%CV) levels of two control materials were measured to be 0.0% and 0.8%, while linearity was evaluated, with the R2 value measured to be 0.9993 (0.4-8.4 mg/dL). Compared to the AU5800, the ABL90 FLEX PLUS correlation coefficient (r) was found to be 0.989. The 95% limits of agreement were determined to be -0.649 and 0.643 mg/dL (-18.8% and 17.8%).
The ABL90 FLEX PLUS exhibited good performance for creatinine test. This indicates that the ABL90 FLEX PLUS can be potentially useful in clinical laboratories.


Creatinine; ABL90 FLEX PLUS; Point-of-care testing; Kidney function tests
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