Korean J Vet Res.  2020 Jun;60(2):101-104. 10.14405/kjvr.2020.60.2.101.

Carcinoid tumor of gallbladder in a dog

  • 1Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
  • 2POSTBIO, Inc., Guri 11906, Korea
  • 3Department of Veterinary Pathology, Cheju National University, Jeju 63243, Korea
  • 4W Animal Medical Center, Seoul 04029, Korea
  • 5Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34140, Korea


A 7-year-old female mixed-breed dog was presented to a veterinary clinic for pyometra. During abdominal ultrasonography, an abnormal finding was noted in the gallbladder. A cholecystectomy was performed. Grossly, the gallbladder wall was thickened with a polypoid nodular projection into the lumen. Microscopically, the polyp consisted of a solid sheet of round to polygonal-shaped cells that formed small packets with fibrovascular septa. The neoplastic cells contained abundant cytoplasmic eosinophilic granules. Immunohistochemically, the neoplastic cells were positive to chromogranin A and neuron-specific enolase, whereas they were negative to vimentin and cytokeratin. This case was diagnosed as a primary gallbladder carcinoid tumor.


dog; gallbladder; tumor; carcinoid; neuroendocrine
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