Kidney Res Clin Pract.  2020 Jun;39(2):121-135. 10.23876/j.krcp.20.042.

The KNOW-CKD Study: What we have learned about chronic kidney diseases

  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
  • 2Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea
  • 3Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of Korea
  • 4Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea
  • 5Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • 6Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
  • 7Seoul National University Cancer Research Institute, Seoul, Republic of Korea
  • 8Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea


As the nation’s largest chronic kidney disease (CKD) cohort, the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was established to investigate the clinical course, risk factors for progression, and adverse outcomes of CKD. From 2011 to 2016, the KNOW-CKD recruited 2,238 adult patients with CKD from stage G1 to G5 who were not receiving renal replacement therapy from nine tertiary care hospitals throughout Korea. As of 2019, the KNOW-CKD has published more than 50 articles in the areas of socio-economics, nutrition, quality of life, health-related habits, CKD progression, cardiovascular comorbidity and outcome, anemia, mineral bone disease, biomarker discovery, and international and inter-ethnic comparisons. The KNOW-CKD will eventually offer a prediction model for long-term consequences of CKD, such as the occurrences of end-stage renal disease, cardiovascular disease, and death, thereby enabling the identification and treatment of at-risk populations that require extra medical attention.


Chronic kidney disease; Cohort studies; Korea; Outcome
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