Korean J Psychosom Med.  2020 Jun;28(1):81-88. 10.22722/KJPM.2020.28.1.81.

Comparisons of HRV Parameters Among Anxiety Disorder, Depressive Disorder and Trauma·Stressor Related Disorder

Affiliations
  • 1Departments of Psychiatry, National Center for Mental Health, Seoul, Korea
  • 2Departments of Anxiety and Stress Disorder, National Center for Mental Health, Seoul, Korea
  • 3Mental Health Research Institute, National Center for Mental Health, Seoul, Korea
  • 4Division of Disaster Mental Health Services, National Center for Mental Health, Seoul, Korea

Abstract


Objectives
:This study aimed to compare autonomic nervous system (ANS) dysregulation and differential relationships with clinical severities between anxiety disorder, depressive disorder, and trauma·stressor related disorder using heart rate variability (HRV) parameters.
Methods
:We conducted a retrospective chart review of outpatients from 2017 to 2018 in Stress Clinic of National Center for Mental Health. Total 473 patients were included; 166 anxiety disorder; 184 depressive disorder ; 123 trauma·stressor related disorder. Parameters of 5-min analysis of HRV were compared in three groups. Additionally, we investigated the differential association of each parameters with Clinical Global Impression-Severity Scale (CGI-S) across each group.
Results
:No significant differences were found in all HRV parameters between the three groups. However, significant group interactions by CGI-S were found in standard deviation of all RR intervals (SDNN) and the square root of the mean squared differences of successive normal-to-normal intervals (RMSSD) (SDNN, p=0.017 ; RMSSD, p=0.034). A negative relationship between CGI-S and SDNN, RMSSD has been found in anxiety disorder and depressive disorder. However, a positive relationship between CGI-S and SDNN, RMSSD has been found in trauma·stressor related disorder.
Conclusions
:Despite of no significant differences of each HRV parameter, our findings suggested the differential associations of HRV parameters with clinical severity among anxiety disorder, depressive disorder and trauma·stressor related disorder. In trauma·stressor related disorder, the clinical severity and degree of ANS dysregulation may differ, so more aggressive treatment is suggested.

Keyword

Anxiety disorder; Depressive disorder; Trauma-and Stressor-Related Disorder; Heart rate variability; Clinical global impression
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