J Korean Assoc Oral Maxillofac Surg.
2020 Apr;46(2):99-107. 10.5125/jkaoms.2020.46.2.99.
Analyzing the factors that influence occult metastasis in oral tongue cancer
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
- 2Department of Oral and Maxillofacial Surgery, Dankook University Jukjeon Dental Hospital, Yongin, Korea
- 3Department of Oral Pathology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
- KMID: 2500665
- DOI: http://doi.org/10.5125/jkaoms.2020.46.2.99
Abstract
Objectives
We accessed the various clinico-histopathological factors, and their association with occult metastasis (OM) in oral tongue squamous cell carcinoma (OTSCC).
Materials and Methods
One hundred-nine patients with OTSCC were divided into the elective neck dissection (END) group and the watchful waiting (WW) group. Age, sex, T-stage, depth of invasion and differentiation were evaluated to determine the correlation between clinico-histopathological factors and OM. For immunohistochemical analysis, paraffin-embedded blocks of 41 OTSCC specimens were examined with antibodies (VEGF-c, c-Met, and ROR1).
Results
The group with tumor thickness of oral tongue cancer ≥3 mm had higher incidence of OM than those with a thickness of <3 mm. The depth of invasion was statistically correlated with OM (P=0.022). Immunohistochemical analysis showed that high expression of VEGF-c (P=0.043), c-Met (P=0.009), and ROR-1 (P=0.003) were statistically correlated with OM.
Conclusion
The analysis of these clinico-histopathological and immunohistochemical factors can help to determine neck dissection in clinically negative (cN0) patients.
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