J Neurogastroenterol Motil.  2020 Jan;26(1):29-50. 10.5056/jnm19209.

Clinical Practice Guidelines for Functional Dyspepsia in Korea

  • 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 2Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea
  • 3Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea
  • 4Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea
  • 5Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea
  • 6Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
  • 7Department of Internal Medicine, Gangneung Asan Hospital, Universityof Ulsan College of Medicine, Gangneung, Gangwon-do, Korea
  • 8Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungcheongnam-do, Korea
  • 9Department of Internal Medicine, International St. Mary’s Hospital, College of Medicine, Catholic Kwandong University, Incheon, Korea
  • 10Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea
  • 11Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
  • 12Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea


Functional dyspepsia (FD) is a chronic upper gastrointestinal (GI) symptom complex that routine diagnostic work-up, such as endoscopy, blood laboratory analysis, or radiological examination, fails to identify a cause. It is highly prevalent in the World population, and its response to the various available therapeutic strategies is only modest because of the heterogenous nature of its pathogenesis. Therefore, FD represents a heavy medical burden for healthcare systems. We constituted a guideline development committee to review the existing guidelines on the management of functional dyspepsia. This committee drafted statements and conducted a systematic review and meta-analysis of various studies, guidelines, and randomized control trials. External review was also conducted by selected experts. These clinical practice guidelines for FD were developed based on evidence recently accumulated with the revised version of FD guidelines released in 2011 by the Korean Society of Neurogastroenterology and Motility. These guidelines apply to adults with chronic symptoms of FD and include the diagnostic role of endoscopy, Helicobacter pylori screening, and systematic review and meta-analyses of the various treatment options for FD (proton pump inhibitors, H. pylori eradication, and tricyclic antidepressants), especially according to the FD subtype. The purpose of these new guidelines is to aid the understanding, diagnosis, and treatment of FD, and the targets of the guidelines are clinicians, healthcare workers at the forefront of patient care, patients, and medical students. The guidelines will continue to be revised and updated periodically.


Dyspepsia; Endoscopy; Evidence-based medicine; Guideline; Proton pump inhibitors
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