Korean J Biol Psychiatry.  2020 Apr;27(1):1-8. 10.22857/kjbp.2020.27.1.001.

The Determination of the Duration of ElectroconvulsiveTherapy-Induced Seizure Using Local Standard Deviationof the Electroencephalogram Signal and the Changesof the RR Interval of Electrocardiogram

Affiliations
  • 1Mental Health Center, Seoul National University Health Care Center, Seoul, Korea
  • 2Department of Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 3Department of Psychiatry, Institute of Clinical Psychopharmacology, Dongguk University Ilsan Hospital, Goyang, Korea
  • 4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea
  • 5Seoul Chung Psychiatry Clinic, Seoul, Korea
  • 6Department of Computer Simulation, Institute of Basic Science, Inje University, Gimhae, Korea
  • 7Department of Psychiatry, Eulji Medical Center, Eulji Univertisy, Seoul, Korea
  • 8Department of Psychiatry and Behavioral Science, Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Korea

Abstract


Objectives
ZZIn electroconvulsive therapy (ECT) research and practice, the precise determination of seizure duration is important in the evaluation of clinical relevance of the ECT-induced seizure. In this study, we have developed computerized algorithms to assess the duration of ECT-induced seizure.
Methods
ZZSubjects included 5 males and 6 females, with the mean age of 33.1 years. Total 55 ECT sessions were included in the analysis. We analyzed the standard deviation of a finite block of electroencephalography (EEG) data and the change in the local slope of RR intervals in electrocardiography (ECG) signals during ECT-induced seizure. And then, we compared the calculated seizure durations from EEG recording (EEG algorithm) and ECG recording (ECG algorithm) with values determined by consensus of clinicians based on the recorded EEG (EEG consensus), as a gold standard criterion, in order to testify the computational validity of our algorithms.
Results
ZZThe mean seizure durations calculated by each method were not significantly different in sessions with abrupt flattened postictal suppression and in sessions with non-abrupt flattened postictal suppression. The intraclass correlation coefficients (95% confidence interval) of the three methods (EEG algorithm, ECG algorithm, EEG consensus) were significant in the total sessions [0.79 (0.70–0.86)], the abrupt flattened postictal suppression sessions [0.84 (0.74–0.91)], and the non-abrupt flattened postictal suppression sessions [0.67 (0.45–0.84)]. Correlations between three methods were also statistically significant, regardless of abruptness of transition.
Conclusions
ZZOur proposed algorithms could reliably measure the duration of ECT-induced seizure, even in sessions with nonabrupt transitions to flat postictal suppression, in which it is typically difficult to determine the seizure duration.

Keyword

Electroconvulsive therapy; Electrocardiography; Electroencephalography; Postictal suppression; Seizure duration
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