J Bacteriol Virol.  2020 Mar;50(1):55-63. 10.4167/jbv.2020.50.1.055.

Anticoccidial Effect of CS 32 Compounds Against Eimeria tenella Infection in Chickens

  • 1Department of Veterinary Surgery, College of Veterinary Medicine, BK21 Plus Project Team, Chonnam National University, Gwangju 61186, Korea. vetkang@chonnam.ac.kr
  • 2Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.
  • 3Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.
  • 4Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 61452, Korea.


Coccidiosis-causing Eimeria species are transmitted in poultry via the oral-fecal route and can lead to hemorrhagic diarrhea and mortality. This results in enormous economic losses in the poultry industry. Furthermore, its resistance to some currently used antibiotics is increasing. This has prompted the development of new alternative drug therapies that address the issue of chemical-free meat production. Effective management of infectious diseases in veterinary practice includes the induction of protective and adaptive immunity by treatment with an alternative agent. In this study, we evaluated the anticoccidial effects of dietary supplementation of Chosun University (CS) 32 compounds (0.1% and 1.0%) against Eimeria tenella, which was isolated and purified from the supernatant of culture broth of Bacillus strain (KCTC18250P), as well as its effect on the growth rate and feed efficiency in chickens. Overall, we observed a decrease in lesion scores and oocyte output in CS 32 compounds-treated chickens. We concluded that 0.1% CS 32 compounds displayed anticoccidial effects against E. tenella infection.


CS 32 compounds; anticoccidial effect; E. tenella; chickens
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