Korean Circ J.  2020 May;50(5):379-394. 10.4070/kcj.2019.0400.

Metabolic Crosstalk between the Heart and Fat

Affiliations
  • 1Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. walter.koch@temple.edu

Abstract

It is now recognized that the heart can behave as a true endocrine organ, which can modulate the function of other tissues. Emerging evidence has shown that visceral fat is one such distant organ the heart communicates with. In fact, it appears that bi-directional crosstalk between adipose tissue and the myocardium is crucial to maintenance of normal function in both organs. In particular, factors secreted from the heart are now known to influence the metabolic activity of adipose tissue and other organs, as well as modulate the release of metabolic substrates and signaling molecules from the periphery. This review summarizes current knowledge regarding primary cardiokines and adipokines involved in heart-fat crosstalk, as well as implications of their dysregulation for cardiovascular health.

Keyword

Cardiac myocytes; Adipocytes; Crosstalk; Adipokines; Cardiokines

MeSH Terms

Adipocytes
Adipokines
Adipose Tissue
Heart*
Intra-Abdominal Fat
Myocardium
Myocytes, Cardiac
Adipokines
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