Ann Dermatol.  2020 Apr;32(2):151-154. 10.5021/ad.2020.32.2.151.

Two Cases of Aquagenic Wrinkling of the Palms in Korean Healthy Women: Easily Overlooked Disease

• Choi H
• Bae IH
• Kim MS
• Na CH
• Shin BS

• KMID: 2471342
• DOI: http://doi.org/10.5021/ad.2020.32.2.151

Abstract

Aquagenic wrinkling of the palms (AWP) is a rare condition, which is characterized by appearance of whitish papules and plaques and an excessive wrinkling and swelling of the palmar skin after exposure to water. Herein, we report two cases of AWP. A 17-year-old woman presented prickling focal various sized whitish papules, plaques with wrinkles on both palms after water contact for 6 months ago. Histologic findings were consistent with AWP. A 26-year-old woman presented asymptomatic multiple various sized whitish papules, plaques with wrinkles on both palms after water contact for 1 year ago. Both patients underwent a cystic fibrosis transmembrane conduct receptor test but were negative and improved without any treatment.

Keyword

Aquagenic wrinkling of the palms; Cystic fibrosis

MeSH Terms

Adolescent
Adult
Cystic Fibrosis
Female
Humans
Skin
Water
Water

Figure

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  Fig. 1 Clinical images of the palms after the water provocation test. (A) Whitish papules and edematous wrinkling were observed after 5 minutes on a 17-year-old women. (B) Whitish discoloration and edematous wrinkling were observed within 5 minutes on a 26-year-old women.

• 

  Fig. 2 Histopathological findings of palms. (A) Hyperkeratosis, dilated eccrine duct with acrosyringia after water exposure. (B) Orthokeratosis, hyperkeratosis and acrosyringia after water exposure. (A, B: H&E, magnification, ×100).

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