J Korean Med Sci.  2020 Mar;35(9):e51. 10.3346/jkms.2020.35.e51.

Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. minware2@nate.com
  • 2Department of Translational Research Institute for Intractable Diseases, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Abstract

BACKGROUND
Sugammadex is a new neuromuscular blockade reversal agent. Recently, it has been used in patients under general anesthesia. However, sugammadex could be toxic to fetuses and pediatric patients under 3 years of age. In this study, we demonstrated the safety of sugammadex in fetuses, using zebrafish larvae. Furthermore, its neurotoxicity was evaluated using neuronal cell lines.
METHODS
We used SH-SY5Y cells to determine the viability of neuronal cells treated with sugammadex. Zebrafish larvae were used to determine the teratogenic effects of sugammadex.
RESULTS
Sugammadex showed no adverse effects on neuronal cells and zebrafish larvae. The survival rates of neuronal cells were not different in all concentrations. In addition, the heart formation of zebrafish embryos, which were exposed to various concentrations of sugammadex, were not different.
CONCLUSION
This study demonstrated the feasibility of using sugammadex during pregnancy. However, further clinical studies will be required to extrapolate these results to humans.

Keyword

Sugammadex; Toxicity; Zebrafish

MeSH Terms

Anesthesia, General
Cell Line
Embryonic Structures
Fetus
Heart
Humans
Larva*
Neuromuscular Blockade
Neurons
Pregnancy
Survival Rate
Zebrafish*
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