J Korean Assoc Oral Maxillofac Surg.  2020 Feb;46(1):49-57. 10.5125/jkaoms.2020.46.1.49.

Prescription of antibiotics after tooth extraction in adults: a nationwide study in Korea

Affiliations
  • 1Graduate School of Clinical Dentistry, Korea University, Seoul, Korea. dencyy@naver.com
  • 2Private Practice, Anyang, Korea.

Abstract


OBJECTIVES
This study aimed to understand the nationwide patterns of antibiotic prescription after tooth extraction in adult patients.
MATERIALS AND METHODS
This study analyzed dental records from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database on 503,725 tooth extractions performed in adults (≥19 years) during 2011-2015. Patient sex, age, household income, systemic disease (diabetes mellitus and hypertension), type of dental institution, region of dental institution, year of prescription, and type of tooth extraction procedure were considered. The antibiotic prescription rate and broad-spectrum antibiotic prescription frequency were analyzed using chi-squared tests. Factors affecting the prescription of broad-spectrum antibiotics were evaluated using multivariate logistic regression analysis.
RESULTS
The rate of antibiotic prescription after tooth extraction was 81.85%. Penicillin was most commonly prescribed (45.25%), followed by penicillin with beta-lactamase inhibitors (18.76%), metronidazole (12.29%), and second- to fourth-generation cephalosporins (11.52%). The proportion of broad-spectrum antibiotics used among all prescribed antibiotics was 45.88%.
CONCLUSION
The findings of this study demonstrate that the rate of antibiotic prescription after tooth extraction is higher in Korea than in other countries. Furthermore, broad-spectrum antibiotics are used more frequently, which may indicate unnecessary drug prescription, an important contributor to antibiotic resistance.

Keyword

Anti-bacterial agents; Antibiotics; Korea; Prescriptions; Tooth extraction

MeSH Terms

Adult*
Anti-Bacterial Agents*
beta-Lactamase Inhibitors
Cephalosporins
Cohort Studies
Dental Records
Drug Prescriptions
Drug Resistance, Microbial
Family Characteristics
Humans
Korea*
Logistic Models
Metronidazole
National Health Programs
Penicillins
Prescriptions*
Tooth Extraction*
Tooth*
Anti-Bacterial Agents
Cephalosporins
Metronidazole
Penicillins
beta-Lactamase Inhibitors
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